I usually take one Dramamine or Bonine -Non Drowsy formula about an hour before sailing and that's it for the cruise. I haven't been seasick yet, thank goodness, but it makes my mouth dry. Hubby's doctor refused to prescribe him the patch (he already had one from another dr.)--he said there were problems associated with it--I don't remember what. But sure enough on our next cruise, the wife of a couple we befriended had on a patch and couldn't figure out why she was so sick. She took off the patch and a day or so later she was better.