I know this is an old thread, but Genoa is very safe and a very beautiful port. Sailed to and from Genoa Feb 25, 2012 and the train station is within walking distanceif your luggage is not too big or heavy. It is uphill. MSC makes you leave your cabin at 7 am on disembarkation day, so get on and off in Genoa, which docks at 8 am instead of Barcelona, which docks at 1 pm. Everyone has to sit in all the public areas with all of their carry on luggage from 7am until disembarkation. But go! The MSC Spendida is a beautiful ship and Genoa is magical.